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. 2020 May 7;13:3853–3866. doi: 10.2147/OTT.S232918

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© 2020 Liu and Wang.

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OIP5-AS1 depletion decreased CDDP resistance in MG63/CDDP and Saos-2/CDDP cells by regulating miR-377-3p. (A–I) The MG63/CDDP and Saos-2/CDDP cells were transfected with si-NC, si-OIP5-AS1, si-OIP5-AS1 + anti-miR-NC, or si-OIP5-AS1 + anti-miR-377-3p. (A) The level of miR-377-3p was examined by qRT-PCR. (B–D) The IC₅₀ value of CDDP was evaluated via CCK-8 assay. (E and F) The cell viability was detected by CCK-8 assay. (G and H) The apoptotic rate was tested through flow cytometry. (I and J) The protein levels of Bcl-2, Bax, and cleaved-caspase-3 were assessed via Western blot assay. *P<0.05.