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. 2020 May 7;13:3853–3866. doi: 10.2147/OTT.S232918

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© 2020 Liu and Wang.

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MiR-377-3p overexpression enhanced CDDP sensitivity in MG63/CDDP and Saos-2/CDDP cells by modulating FOSL2. (A–M) The MG63/CDDP and Saos-2/CDDP cells were transfected with miR-NC, miR-377-3p, miR-377-3p + pcDNA-NC, or miR-377-3p + pcDNA-FOSL2. (A–D) The mRNA and protein levels of FOSL2 were detected by qRT-PCR and Western blot assay, respectively. (E–G) The IC₅₀ value of CDDP was measured via CCK-8 assay. (H and I) The cell viability was tested by CCK-8 assay. (J and K) The apoptotic rate was examined through flow cytometry. (L and M) The protein levels of Bcl-2, Bax, and cleaved-caspase-3 were detected via Western blot assay. *P<0.05.