Table 3.

Reported Adverse Effects with Clonidine Use in Children and Adults with ASD^*

Study	Adverse Effects with Clonidine Use
Blew, Luiselli, & Thibadeau, 1999	Lethargy, asymptomatic hypotension
Dowben, Grant, & Keltner, 2011	Weight gain of 5–6 lbs (2.3–2.6kg)
Fankhauser et al., 1992	Sedation, fatigue, irritation at transdermal patch site
Ghaziuddin, Tsai, & Ghaziuddin, 1992	Sedation, asymptomatic hypotension
Jaselskis et al., 1992	Drowsiness, decreased level of activity, asymptomatic hypotension, irritability
Koshes & Rock, 1994	Transdermal patch losing adhesiveness
McCracken & Martin, 1997	“Severe syndromal depression”, self-injurious behaviours, worsened aggression
Ming, et al., 2008	Sedation, lethargy, asymptomatic hypotension, tachycardia, skin irritation at transdermal patch site

^*Two case reports were not included as neither reported any adverse effects.