Figure 1. Sensory neurons regulate peroxide resistance in C. elegans.

(A) Peroxide resistance of nematodes with defects in sensory cilia and sensory transduction, or with genetic ablation of specific sensory neurons. The fraction of nematodes remaining alive in the presence of 6 mM tert-butyl hydroperoxide (tBuOOH) is plotted against time. Interventions that increased, decreased, or did not affect survival are denoted in blue, red, and gray, respectively, and their effects on mean peroxide resistance are noted. (B) Specific sensory neurons normally reduce (blue) or increase (red) peroxide resistance. Circle area denotes the effect of ablation of the respective neurons on mean peroxide resistance. (C) Sensory neurons are grouped by the stimuli they sense. Neurons that normally reduce (seven classes) or increase (three classes) peroxide resistance are shown in blue and red, respectively. See also Figure 1—figure supplement 1. Statistical analyses are in Supplementary file 1.

Figure 1—figure supplement 1. Sensory neurons regulate peroxide resistance in C. elegans.

(A–G) Peroxide resistance of nematodes with defects in sensory transduction, or with genetic ablation of specific sensory neurons. The fraction of nematodes remaining alive in the presence of 6 mM tert-butyl hydroperoxide (tBuOOH) is plotted against time. Interventions that increased or did not affect survival are denoted in blue and gray, respectively, and their effect on mean peroxide resistance is noted. Statistical analyses are in Supplementary file 1.