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. 2020 May 5;9:e56186. doi: 10.7554/eLife.56186

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© 2020, Schiffer et al

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Figure 6. — (A) Volcano plot showing the level and statistical significance of changes in gene expression induced by the daf-7(ok3125) null mutation. Genes up- and down-regulated significantly (q value < 0.001) are shown in red and blue, respectively. (B) Gene Ontology (GO) term enrichment analysis of biological processes associated with the set of 594 upregulated genes (blue bubbles) and the set of 1267 downregulated genes (red bubbles) with a statistically significant and greater than four-fold change in expression in daf-7(ok3125) mutants relative to wild-type animals. Bubble size is proportional to the statistical significance [-log₁₀(P value)] of enrichment. (C) The daf-7(ok3125) mutation increased the expression of genes upregulated by skn-1(+) in wild type animals (Oliveira et al., 2009). (D) The daf-7(ok3125) mutation increased the expression of genes directly upregulated by DAF-16 (Kumar et al., 2015). See also Figure 6—figure supplement 1. Additional statistical analyses are in Supplementary file 6.

Figure 6—figure supplement 1. — (A) Volcano plot showing the level and statistical significance of changes in gene expression induced by the daf-7(ok3125) null mutation. Genes up- and down-regulated significantly (q value < 0.001) are shown in red and blue, respectively. (B) Gene Ontology (GO) term enrichment analysis of biological processes associated with the set of 594 upregulated genes (blue bubbles) and the set of 1267 downregulated genes (red bubbles) with a statistically significant and greater than four-fold change in expression in daf-7(ok3125) mutants relative to wild-type animals. Bubble size is proportional to the statistical significance [-log₁₀(P value)] of enrichment. (C) The daf-7(ok3125) mutation increased the expression of genes upregulated by skn-1(+) in wild type animals (Oliveira et al., 2009). (D) The daf-7(ok3125) mutation increased the expression of genes directly upregulated by DAF-16 (Kumar et al., 2015). See also Figure 6—figure supplement 1. Additional statistical analyses are in Supplementary file 6.