Table 2. Parameters thatĀ areĀ most predictive of protection.
| Cell type | Phenotype | Parameter | Weight |
|---|---|---|---|
| B cell | Memory B cell ELISpot | PF.CSP.T2 | 79 |
| PF.16.T4 | 64 | ||
| PF.CSP.T5 | 53 | ||
| T cell | CD40L+CD4 | CD40L.CSP.T4 | 100 |
| CD40L.CSP.T6 | 57 | ||
| CD40L.CSP.T2 | 52 | ||
| Ag.pTfh | Ag.pTfh.CSP.T2 | 71 | |
| Ag.pTfh.IL.21.HBs.T4 | 60 | ||
| Ag.pTfh.IL.21.CSP.T6 | 56 | ||
| Ag.pTfh.IL.21.HBs.T6 | 55 | ||
| Ag.pTfh.IL.21.CSP.T4 | 49 | ||
| Total. pTfh | Total.pTfh.MED.T2 | 49 | |
| Total.pTfh.MED.T4 | 43 | ||
| Total.pTfh.MED.T6 | 40 | ||
| Ag.CD4 | CSP.T4 | 46 | |
| CSP.T6 | 38 | ||
| MED.T6 | 42 | ||
| HBs.T4 | 52 |
Abbreviations: Ag.pTfh, antigen specific peripheral T follicular helper cells; Ag.CD4, antigen stimulated total CD4 T cells; ELIspot, memory B cell ELISpot responses; CD40L+CD4, CD40L+ CD4 T cells.