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. 2020 Jan 31;36(10):2980–2985. doi: 10.1093/bioinformatics/btaa073

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© The Author(s) 2020. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fig. 4. — Performance profiling. (A) Runtime (seconds) of coolpup.py with varying number of averaged ‘loops’ for two Hi-C datasets with different depth. (B) Same as (A), but for number of linear regions between which interactions are averaged. Also shown is runtime for HiCExplorer hicAggregateContacts. Note that the longest time-point for HiCExplorer required over 512 Gb RAM and was not computed. (С) Runtime of the same analysis with 5000 linear regions and a varying number of cores. Same colour coding as in (A)