Fig. 1.

Overview of scBatch workflow. For the preprocessed count matrix X, the Pearson correlation matrix is corrected by QuantNorm to obtain a reference sample distance matrix D. Then the main algorithm is utilized to search for the weight matrix W to achieve the objective that the Pearson correlation of X × W is close to D. The corrected count matrix $Y=X\times W$ inherits the sample pattern information from D, which can be used for downstream analyses