Table 3. Main Results of the Pooled ORs in Meta-Analysis of the Associations between Inflammatory Cytokine Gene Polymorphisms and Intracranial Aneurysm.
| Gene SNPs | N | Sample size (case/control) | Dominant model | Allelic model | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| OR (95% CI) | I2 (%) | PQ | PZ | OR (95% CI) | I2 (%) | PQ | PZ | |||
| TNF-α rs1800629 | 3 | 424/475 | 0.65 (0.47–0.89) | 36.5 | 0.212 | 0.007 | 0.74 (0.56–0.97) | 7.7 | 0.338 | 0.030 |
| IL-1α rs1800587 | 2 | 435/405 | 1.02 (0.77–1.34) | 0.0 | 0.590 | 0.903 | 1.11 (0.91–1.37) | 0.0 | 0.916 | 0.307 |
| IL-1β rs16944 | 3 | 666/636 | 1.03 (0.83–1.29) | 0.0 | 0.541 | 0.786 | 1.09 (0.93–1.28) | 35.2 | 0.214 | 0.282 |
| IL6 rs1800795 | 5 | 886/3827 | 0.87 (0.73–1.04) | 46.4 | 0.113 | 0.126 | 0.84 (0.69–1.04)* | 56.8 | 0.055 | 0.114 |
| IL6 rs1800796 | 7 | 1252/3888 | 0.75 (0.38–1.51)* | 89.8 | <0.001 | 0.422 | 0.91 (0.51–1.62)* | 93.8 | <0.001 | 0.735 |
| IL6 rs1800796 subgroup analysis | ||||||||||
| Chinese | 3 | 642/642 | 0.45 (0.07–2.79)* | 95.3 | <0.001 | 0.390 | 0.73 (0.24–2.23)* | 96.6 | <0.001 | 0.579 |
| Caucasian | 4 | 610/3246 | 1.13 (0.87–1.46) | 49.0 | 0.117 | 0.376 | 1.08 (0.75–1.54)* | 61.3 | 0.052 | 0.684 |
| IL-12B rs3212227 | 2 | 384/508 | 1.32 (0.55–3.18)* | 87.9 | 0.004 | 0.537 | 1.19 (0.81–1.74)* | 74.3 | 0.048 | 0.373 |
SNPs, single nucleotide polymorphisms; N, number of studies; I2, Higgins I2 statistic; PQ, value for Q test; PZ value for Z test; OR, odds ratio; CI, confidence interval.
*ORs were calculated in random-effect model.