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. Author manuscript; available in PMC: 2021 Jan 1.
Published in final edited form as: Gerontology. 2019 Nov 28;66(3):212–222. doi: 10.1159/000504294

Figure 4: Decline of regenerative capacity in limbs repeatedly amputated at the same location.

Figure 4:

Example whole-mount skeletal preparations of the resulting regenerates form from limbs that have been amputated in the same location 1, 2, 3, 4, or 5 times. Bryant et al. observed a marked decrease in regenerative potential with increasing number of amputations (republished with permission from [23]).