. 2020 Apr 16;24(10):5528–5541. doi: 10.1111/jcmm.15209

Table 2.

Differentially expressed mRNAs (vs Sham, x‐fold, means ± SD) and effect of protection

	I/R	IPC	IPoC‐R	IPoC‐NR	ANOVA
Up
MMP12	21.18 ± 12.62^a	1.61 ± 1.51^b	1.26 ± 0.94^b	10.68 ± 10.62	P = .005
ANP	18.13 ± 1.47^a	9.57 ± 0.33^a,b	26.56 ± 15.67^a	40.00 ± 25.57^a	P = .015
Coll‐3	8.54 ± 1.30^a	0.96 ± 0.74^b	0.61 ± 0.25^b	4.13 ± 3.71	P < .000
Biglycan	6.24 ± 1.14^a	2.92 ± 3.25	1.20 ± 1.10^b	3.90 ± 2.36	P = .004
Coll‐1	5.22 ± 1.40^a	2.54 ± 2.60	1.14 ± 1.08^b	2.66 ± 1.73	P = .013
Elastin	4.56 ± 0.21^a	0.82 ± 0.60^b	0.85 ± 0.52^b	4.07 ± 1.87	P < .000
p91^phox	4.50 ± 2.20^a	0.22 ± 0.18	0.09 ± 0.04	0.96 ± 1.33	P = .001
EFhd2	3.55 ± 0.93^a	1.47 ± 0.18	0.48 ± 0.22	1.46 ± 0.84	P < .000
SOD‐3	3.22 ± 1.15	3.16 ± 1.87	1.87 ± 1.00	2.94 ± 0.30	P = .073
Fibronectin	2.32 ± 0.90	1.49 ± 1.66	0.43 ± 0.46	1.35 ± 0.95	P = .132
Down
Elfn2	0.05 ± 0.01	0.07 ± 0.02	0.03 ± 0.01	0.03 ± 0.01	P = .080
Kchn5	0.06 ± 0.03^a	0.20 ± 0.07^a,b	0.12 ± 0.04^a	0.27 ± 0.23^a	P = .013
Scn8a	0.08 ± 0.01	0.21 ± 0.03^b	0.06 ± 0.01	0.09 ± 0.05	P = .041
Socs7	0.13 ± 0.04	0.07 ± 0.04	0.02 ± 0.00	0.05 ± 0.00	P = .035
FOXc2	0.16 ± 0.02	0.09 ± 0.07	0.04 ± 0.02	0.08 ± 0.07	P = .049
Slc5a3	0.17 ± 0.05^a	0.26 ± 0.10^a	0.10 ± 0.02^a	0.19 ± 0.13^a	P = .002
MHC‐α	0.28 ± 0.08	0.49 ± 0.39	0.76 ± 0.31	0.43 ± 0.21	P = .072
PGC‐1α	0.48 ± 0.19	0.42 ± 0.24	0.70 ± 0.14	0.60 ± 0.19	P = .094
Laminin	0.49 ± 0.06^a	0.37 ± 0.15^a	0.36 ± 0.04^a	0.49 ± 0.10^a	P = .019
PLB	0.50 ± 0.05	2.05 ± 1.84	2.15 ± 0.58	1.23 ± 0.93	P = .222

Abbreviations: ANP, atrial natriuretic peptide; Coll, collagen; Elfn, extracellular leucin‐rich repeat and fibronectin type III domain‐containg protein 2; Fox, forkhead box protein; Kchn, Potassium voltage‐gated channel, subfamily H; MHC, myosin heavy chain; MMP, matrix metalloprotease; PGC, PPAR gamma co‐activator; PLB, phospholamban; Scn, Sodium channel, voltage gated; Slc, Sodium‐Myoinositol cotransporter; Socs, Supressor of cytokine signalling; SOD, superoxide dismutase.