Table 3.

Genes that are differentially expressed by IPoC‐R and IPoC‐NR and its comparison to IPC

Protein	I/R	IPoC‐R	IPoC‐NR	IPC
Regulated by all three conditionings (n = 3)
Arrestin‐β2	1.97 ± 0.42	0.38 ± 0.36***	0.71 ± 0.50*	0.79 ± 0.55*
FOXn3	1.48 ± 0.18	0.68 ± 0.35**	0.74 ± 0.38*	0.55 ± 0.17***
Zbtb20	0.77 ± 0.14	0.35 ± 0.19*	0.37 ± 0.16*	0.45 ± 0.15*
Selectively Regulated by IPoC‐R and IPoC‐NR but not by IPC (n = 3)
EFhd2	2.49 ± 0.66	0.33 ± 0.15**	1.03 ± 0.59*	1.03 ± 0.83
GRK2	1.39 ± 0.13	0.05 ± 0.02***	0.46 ± 0.31**	0.95 ± 0.51
VEGF‐A	0.69 ± 0.04	1.60 ± 0.23**	1.65 ± 0.20**	0.90 ± 0.50
Selectively Regulated by IPoC‐R and IPC (n = 7)
Coll‐3	4.26 ± 0.65	0.30 ± 0.13**	2.06 ± 1.85	0.48 ± 0.37**
Elastin	3.02 ± 0.14	0.56 ± 0.34***	2.69 ± 1.24	0.54 ± 0.40**
Psme3	1.31 ± 0.34	0.61 ± 0.27*	0.74 ± 0.24	0.60 ± 0.10*
Arginase‐1	1.18 ± 0.18	0.14 ± 0.05**	1.02 ± 0.77	0.33 ± 0.19**
CaSR	0.89 ± 0.34	0.05 ± 0.01*	0.32 ± 0.22	0.15 ± 0.09*
Bcl‐2	0.82 ± 0.15	0.36 ± 0.09*	0.75 ± 0.05	0.36 ± 0.09*
Intermedin	0.71 ± 0.30	0.03 ± 0.01*	0.35 ± 0.31	0.09 ± 0.05*
Selectively Regulated by IPoC‐R (n = 21)
Biglycan	4.64 ± 0.85	0.89 ± 0.82***	2.90 ± 1.75	2.17 ± 2.42
Coll‐1	3.62 ± 0.97	0.79 ± 0.75**	1.85 ± 1.20	1.76 ± 1.80
NOX2	2.43 ± 1.19	0.05 ± 0.02*	0.52 ± 0.72	0.12 ± 0.10
Fibronectin	2.13 ± 0.83	0.40 ± 0.42*	1.24 ± 0.87	1.36 ± 1.52
JDP2	1.76 ± 0.47	0.44 ± 0.30**	1.11 ± 0.65	1.52 ± 0.45
TGF‐β1	1.71 ± 0.15	0.54 ± 0.32**	1.24 ± 0.67	1.36 ± 0.13
RAMP‐1	1.32 ± 0.39	0.17 ± 0.07*	0.77 ± 0.51	0.29 ± 0.09
PTHrP	1.24 ± 0.52	0.20 ± 0.06*	0.76 ± 0.11	0.62 ± 0.35
RAMP‐3	1.17 ± 0.43	0.29 ± 0.09*	0.74 ± 0.50	1.19 ± 0.73
iNOS	1.09 ± 0.03	0.39 ± 0.14**	0.92 ± 0.29	0.77 ± 0.34
Arginase‐2	1.05 ± 0.18	0.21 ± 0.10***	0.61 ± 0.35	0.80 ± 0.48
Arrestin‐β1	1.05 ± 0.35	0.29 ± 0.31*	0.58 ± 0.29	0.49 ± 0.27
eNOS	1.03 ± 0.08	0.50 ± 0.11***	0.73 ± 0.20	0.74 ± 0.48
RAMP‐2	0.98 ± 0.35	0.26 ± 0.05*	0.65 ± 0.32	0.74 ± 0.50
GRK5	0.97 ± 0.15	0.28 ± 0.13***	0.59 ± 0.28	0.76 ± 0.38
MDM2	0.94 ± 0.17	0.48 ± 0.22*	0.67 ± 0.36	1.25 ± 0.64
SDF‐1α	0.90 ± 0.15	0.29 ± 0.21**	0.50 ± 0.20	1.21 ± 1.07
Oxsr1	0.75 ± 0.18	0.36 ± 0.15*	0.48 ± 0.28	0.41 ± 0.19
Ppargc1b	0.71 ± 0.25	0.23 ± 0.15*	0.25 ± 0.16	0.31 ± 0.09
SERCA2a	0.70 ± 0.16	9.74 ± 4.74*	5.02 ± 5.34	2.99 ± 2.47
AR‐B2	0.68 ± 0.04	0.26 ± 0.06***	0.68 ± 0.27	0.68 ± 0.04
PLB	0.41 ± 0.04	1.74 ± 0.47	0.99 ± 0.75	1.66 ± 0.49
Socs7	0.19 ± 0.05	0.05 ± 0.03*	0.12 ± 0.12	0.19 ± 0.18

Abbreviations: AR, adrenoceptor; bcl, B‐cell lymphoma; CaSR, calcium sensing receptor; Coll, collagen; EFhd, EF‐hand domain; FOX, forkhead box protein; GRK, G‐protein coupled receptor; JDP2, jun dimerization protein; MDM mouse double minute; NOS, nitric oxide synthase; NOX, NADPH oxidase; Oxsr, oxidative stress response; PLB, phospholamban; Ppargc, peroxisome proliferator‐activated receptor gamma co‐activator gamma; Psme, proteome activator subunit; PTHrP, parathyroid hormone‐related protein; RAMP, receptor activator modifying protein; SDF, stromal derived factor; SERCA, sarcoplamatic reticulum receptor calcium ATPase; Socs, Supressor of cytokine signalling; TGF, transforming growth factor; VEGF, vascular endothelial growth factor; Zbtb, Zinc‐finger and BTB‐containing protein.

^* P < .05 vs I/R

^** P < .01 vs I/R

^*** P < .001 vs I/R.