FIGURE 1.

Dysregulation of HK2 in TMZ resistant GBM leads to poor survival. A, The expression of HK2 from GEO database (GSE2221). B, The HK2 mRNA level in U87 and A172 parental and TMZ resistant cells. C, Western blot of HK2 in U87 and A172 parental and TMZ resistant cells. D, The mRNA level of HK2 in GBM tissues from 38 patients received TMZ treatment (responsive patients: 24 patients without tumour recurrence; resistant patients: 14 patients with tumour recurrence). E, The representative IHC of HK2 in tumours from TMZ responsive and resistant GBM patients. F, The overall survival of 38 GBM patients with different level of HK2 expression. G, The HK2 expression from TCGA GBM RNAseq (IlluminaHiSeq) dataset (N = 671) (https://xenabrowser.net/heatmap/). Data were represented in means ± SEM. *P < .05; **P < .01; ***P < .001