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Open field exploratory locomotion in 12 month old Ube3a and WT mice. A) Horizontal activity was lower in Ube3a than WT (***p<0.001). B) Vertical activity was lower in Ube3a mice at most time points (*p=0.05). C) Center time was lower in Ube3a (*p<0.05). D) Total distance traveled was lower in Ube3a (***p<0.001). E) Summed total distance was lower in Ube3a (**p<0.001), supporting the interpretation of reduced general exploratory locomotion in the older 12 month old mice.
