Table 3:

Discrimination powers calculated as the area under the curve (AUC) and pair-wise comparisons

MSON vs. HC	AUC (P Value)	RVD	SVD	DVD	4 Layers	RNFL+GCIPL	INL+OPL	VVDr	VVDs	VVDd
RVD	0.54 (P= .477)
SVD	0.50 (P= .972)	P= .133
DVD	0.63 (P= .006)	P= .009	P= .001
4 Layers	0.87 (P< .001)	P< .001	P< .001	P< .001
RNFL+GCIPL	0.87 (P< .001)	P< .001	P< .001	P< .001	P= .972
INL+OPL	0.71 (P< .001)	P= .005	P= .001	P= .237	P< .001	P= .001
VVDr	0.87 (P<.001)	P< .001	P< .001	P< .001	P= .400	P= .841	P< .001
VVDs	0.84 (P< .001)	P< .001	P< .001	P< .001	P=.113	P= .001	P= .004	P= .072
VVDd	0.76 (P< .001)	P= .001	P< .001	P= .057	P= .002	P= .011	P< .001	P= .001	P= .051
Multivariatea	0.94 (P< .001)	P< .001	P< .001	P< .001	P= .002	P= .003	P< .001	P= .002	P= .001	P< .001
MSNON vs. HC	AUC (P Value)	RVD	SVD	DVD	4 Layers	RNFL+GCIPL	INL+OPL	VVDr	VVDs	VVDd
RVD	0.59 (P= .007)
SVD	0.58 (P= .015)	P= .419
DVD	0.54 (P= .282)	P= .054	P= .127
4 Layers	0.61 (P= .001)	P= .641	P= .510	P= .134
RNFL+GCIPL	0.61 (P= .001)	P= .681	P= .545	P= .161	P= .868
INL+OPL	0.59 (P= .007)	P= .945	P= .795	P= .238	P= .328	P= .603
VVDr	0.61 (P= .001)	P= .557	P= .429	P= .100	P= .169	P= .649	P= .222
VVDs	0.58 (P= .018)	P= .874	P= .975	P= .377	P= .061	P< .001	P= .733	P= .027
VVDd	0.65 (P< .001)	P= .189	P= .129	P= .011	P= .072	P= .225	P< .001	P= .112	P= .036
Multivariateb	0.89 (P< .001)	P< .001	P< .001	P< .001	P< .001	P< .001	P< .001	P< .001	P< .001	P< .001
MSON vs. MSNON	AUC (P Value)	RVD	SVD	DVD	4 Layers	RNFL+GCIPL	INL+OPL	VVDr	VVDs	VVDd
RVD	0.63 (P= .015)
SVD	0.59 (P= .085)	P= .147
DVD	0.67 (P= .001)	P= .312	P= .063
+4 Layers	0.78 (P< .001)	P= .011	P= .003	P= .082
RNFL+GCIPL	0.80 (P< .001)	P= .003	P= .001	P= .028	P= .169
INL+OPL	0.62 (P= .023)	P= .889	P= .697	P= .489	P< .001	P< .001
VVDr	0.78 (P< .001)	P= .016	P= .005	P= .097	P= .506	P= .132	P< .001
VVDs	0.79 (P< .001)	P= .009	P= .003	P= .061	P= .484	P= .071	P= .001	P= .380
VVDd	0.62 (P= .027)	P= .836	P= .762	P= .456	P< .001	P< .001	P= .384	P< .001	P= .001
Multivariatec	0.81 (P< .001)	P< .001	P< .001	P= .002	P= .270	P= .701	P< .001	P= .250	P= .460	P< .001

MSON: multiple sclerosis with a history of optical neuritis; MSNON: multiple sclerosis without a history of optical neuritis; HC: healthy control. RVD: vessel density (Dbox) of retinal vascular network; SVD: vessel density (Dbox) of superficial vascular plexus; DVD: vessel density (Dbox) of deep vascular plexus; RNFL: retinal nerve fiber layer; GCIPL: ganglion cell-inner plexiform layer; INL: inner nuclear layer; OPL: Outer plexiform layer.

^aMultivariate: VVDr, INL+OPL, VVDs, RVD and SVD;

^bMultivariate: VVDd, INL+OPL, DVD, VVDs and VVDr.

^cMultivariate: RNFL+GCIPL and DVD.