Table 1–
Demographic and clinical characteristics of clinical trial (n=53) and healthy control (n=38) participants
| Clinical trial participants (n=53) | Healthy control participants (n=38) | F or X2 | p-value | |
|---|---|---|---|---|
| Female. No. (%) | 14 (26.4) | 16 (42.1) | 2.5 | 0.116 |
| Age, mean (SD) | 35.2 (9.4) | 38.5 (9.1) | 2.8 | 0.097 |
| Educational attainment (some college or above, %) | 18 (34) | 35 (92.1) | 30.8 | <0.001 |
| Methadone dose at baseline (mg), mean (SD) | 74.7 (23.1) | - | - | - |
| Years of regular cocaine use, mean (SD) | 8.1 (6.5) | - | - | - |
| Years of regular opioid use, mean (SD) | 9.2 (7.4) | - | - | - |
| Lifetime cannabis use disorder, No. (%) | 37 (69.8) | - | - | - |
| Lifetime alcohol use disorder, No. (%) | 30 (56.6) | - | - | - |
| No. prior outpatient drug treatments, mean (SD) | 3.0 (3.8) | - | - | - |
| No. prior inpatient drug treatments, mean (SD) | 3.0 (4.7) | - | - | - |
| Lifetime No. of arrests, mean (SD) | 5.3 (6.1) | - | - | - |
| Estimated IQ (Shipley), mean (SD) | 90.1 (12.8) | - | - | - |
| Days in treatment at initial fMRI scan, mean (SD) | 1.5 (6.7) | - | - | - |
| Percent opioid negative urines, mean (SD) | 64.9 (37.1) | - | - | - |
| Percent cocaine negative urines, mean (SD) | 23.0 (28.0) | - | - | - |