Fig. 4.

Tumor rechallenge of C1498-GFP AML surviving mice and adoptive transfer of CD8⁺ T cells. a C1498-GFP AML surviving C57BL/6 mice (n = 7) were rechallenged with 10⁶ C1498-GFP AML cells. No further treatment was applied. Tumor-naive C57BL/6 mice (n = 10) served as controls. Survival data derived from three independent experiments were plotted in a Kaplan–Meier survival curve. b As depicted in the schematic C57BL/6 mice (n = 4) were treated with CD8⁺ T cells from C1498-GFP AML surviving (T cells (survivor), n = 3) or tumor-naive mice (T cells (ctrl), n = 5), respectively. Untreated mice (n = 8) served as controls. C1498-GFP AML was induced 12 h later in all three groups. T cells were isolated as described in the “Materials and methods” section. Survival data derived from two independent experiments were plotted in a Kaplan–Meier survival curve. Significance was calculated using log-rank test