Table 3.
Short intravenous glucose tolerance test outcomes and carbohydrate metabolism parameters at baseline, end of treatment and percent changes from baseline following Egg and Non-Egg conditions in the study completers (N = 30).
| Mean (SEM) or median (IQL) | ||||||
|---|---|---|---|---|---|---|
| Parameter | Baseline | Egg, EOT | Non-Egg, EOT | Egg, % ∆ | Non-Egg, % ∆ | P value |
| ISI × 10−4 min−1 (mU/L)−1 | 8.9 (2.7) | 6.8 (0.9) | 5.4 (0.9) | 15.0 (14.3) | −4.1 (16.8) | 0.193 |
| AIRg, mU/L | 28.2 (19.4, 49.0) | 22.4 (13.8, 55.9) | 34.6 (17.0, 55.2) | −18.7 (−39.5, 14.2) | 3.6 (−35.3, 43.7) | 0.234 |
| DI × 10−4 | 156 (71.1, 324) | 158 (40.1, 296) | 143 (48.6, 289) | −17.3 (−47.2, 33.6) | −18.5 (−63.2, 13.2) | 0.579 |
| Kg, % | 1.6 (1.1, 2.9) | 1.4 (1.2, 2.1) | 1.4 (0.9, 2.0) | −1.5 (−31.8, 48.1) | −6.6 (−33.9, 23.0) | 0.213 |
| Insulin AUC0–10min | 406 (265, 647) | 416 (220, 720) | 499 (299, 679) | −12.1 (−37.7, 25.2) | 5.4 (−12.5, 32.9) | 0.110 |
| Insulin AUC10–40min | 1010 (591, 1868) | 932 (728, 1642) | 1046 (620, 2160) | 2.4 (−15.2, 20.2) | 1.9 (−24.0, 18.0) | 0.808 |
| Insulin AUC0–40min | 1409 (928, 2736) | 1333 (851, 2740) | 1582 (962, 2951) | 1.4 (−18.9, 14.1) | −0.6 (−23.6, 17.7) | 0.708 |
| Fasting glucose, mg/dL | 90.3 (2.7) | 90.8 (2.0) | 92.3 (1.9) | 2.3 (2.8) | 4.1 (3.0) | 0.459 |
| Fasting insulin, mU/L | 9.5 (6.1, 12.1) | 8.2 (5.9, 14.5) | 9.0 (6.1, 15.3) | −0.6 (−23.7, 10.7) | 8.6 (−14.0, 28.1) | 0.057 |
| HOMA2%-B | 101 (83.1, 166) | 89.5 (66.8, 127) | 104 (72.7, 170) | −2.0 (−23.3, 7.4) | −0.6 (−15.6, 15.3) | 0.277 |
| HOMA2%-S | 86.8 (66.4, 122) | 95.0 (55.0, 127) | 85.3 (49.5, 123) | 1.9 (−9.0, 29.1) | −8.5 (−25.2, 15.0) | 0.067 |
| HOMA-IR | 2.5 (0.3) | 2.3 (0.3) | 2.7 (0.3) | 1.4 (9.9) | 24.4 (13.1) | 0.028 |
Units for insulin AUCs are mU/L × min.
% ∆ percent change, AIRg acute insulin response to glucose, AUC area under the curve, DI disposition index, EOT end of treatment, HOMA2%-B homeostasis model assessment 2-beta-cell function, HOMA2-%S homeostasis model assessment 2-insulin sensitivity, HOMA-IR homeostasis model assessment 2-of insulin resistance, IQL interquartile limits, ISI insulin sensitivity index, Kg fractional disappearance of glucose constant, SEM standard error of the mean.
Bold value indicate statistical significant p-value.
P values are for the comparison of treatment conditions in the percent change from baseline.