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. 2019 Nov 12;34(3):857–871. doi: 10.1038/s41375-019-0628-0

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Physiological PI3K-AKT activation in BL. a Immunohistochemical detection of pAKT^T308. Normal tonsillar GC B cells (GC) are weakly positive (+) while follicular mantle B cells (MZ) are strongly positive (+++). In BL pAKT^T308 was weakly positive in most cases. The majority of GCB-DLBCL was clearly positive (++). Left column: Overview. Scale bar represents 200 µm. Right column: Details. Scale bar represents 100 µm. b Table gives details of all cases examined