Table 2.
Comorbidity with liver injury in patients with SARS-CoV-2 infection.
| Study ID | Patients number | Patients with pre-existing liver conditions | Total patients with abnormal liver function | Notes |
|---|---|---|---|---|
| Chen et al. | 249 | 2 (0.8%) patients had chronic hepatitis B virus infection | NA | AST/ALT/ALB levels were within normal range. |
| Chen et al. |
99 | NA | ALT abnormal (28%) AST abnormal (35%) ALB abnormal (98%) TB abnormal (18%) |
43 (43.4%) patients had liver function abnormality, with ALT or AST above the normal range |
| Guan et al. |
1099 | 23 (2.1%) patients had chronic hepatitis B virus infection | ALT abnormal (21.3%) AST abnormal (22.2%) TB abnormal (10.5%) |
ALT abnormal: severe (19.8%) vs. non-severe (28.1%) survival (19.9%) vs. non-survival (40.8%) AST abnormal: severe (39.4%) vs. non-severe (18.2%) survival (20.1%) vs. non-survival (50.0%) TB abnormal: severe (13.3%) vs. non-severe (9.9%) survival (9.8%) vs. non-survival (20.8%) |
| Huang et al. |
41 | 1 (2%) patients had chronic liver disease | AST abnormal (37%) |
AST abnormal: ICU (62%) vs. non-ICU (25%) |
| Huang et al. |
34 | 1 (2.9%) patients had chronic liver disease | ALT abnormal (23.5%) AST abnormal (20.6%) ALB abnormal (73.5%) TB abnormal (8.8%) |
NA |
| Mo et al. |
155 | 7 (4.5%) patients had chronic liver disease | NA | The levels of ALT/AST all increased slightly, but all were within the normal range. The levels of ALB/GLB all decreased slightly, but all were within the normal range. |
| Qian et al. |
91 | NA | ALT abnormal (7.7%) AST abnormal (9.9%) ALB abnormal (47.3%) |
NA |
| Qin et al. |
452 | 6 (1.3%) patients had chronic liver disease | NA | NA |
| Shi et al. |
81 | 7 (9%) patients had chronic liver disease | AST abnormal (53%) |
The average level of ALT was 46.2U/L. |
| Wang et al. |
138 | 4 (2.9%) patients had chronic liver disease | NA | The levels of ALT/AST/TB all increased slightly in the ICU group, but all were within the normal range. |
| Xu et al. |
62 | 7 (11%) patients had chronic liver disease | AST abnormal (16.1%) | The average level of ALT was within the normal range. |
| Yang et al. |
149 | NA | ALT abnormal (12.1%) AST abnormal (18.1%) ALB abnormal (6.0%) TB abnormal (2.68%) |
NA |
| Yang et al. |
52 | NA | Liver dysfunction (29%) | NA |
| Zhang et al. |
645 | 24 (3.7%) patients had chronic liver disease | NA | The levels of ALT/AST/TB all increased in the abnormal CT imaging group, but all were within the normal range. The levels of ALB decreased in the abnormal CT imaging group, but all were within the normal range. |
| Zhang et al. |
140 | 8 (5.7%) patients had fatty liver and abnormal liver function | NA | NA |
| Zhou et al. |
191 | NA | ALT abnormal (31%) | The levels of ALB decreased below the normal range in the non-survival group. |
Abbreviation: AST: aspartate aminotransferase; ALB: albumin; GLB: globulin; ALT: alanine aminotransferase; TB: total bilirubin; ICU: intensive care unit; NA: not applicable.