Table 1.
Patient basal characteristics according to urine TIMP-2/IGFBP7 excretion quartiles
| Characteristic | Total (n = 124) | First (n = 31) (< 1.10) | Second (n = 31) (1.10–1.58) | Third (n = 31) (1.59–2.11) | Fourth (n = 31) (2.12 ≤) | p value |
|---|---|---|---|---|---|---|
| Age, yr | 71.05 ± 14.32 | 73.90 ± 10.73 | 71.16 ± 18.09 | 71.48 ± 13.48 | 67.65 ± 14.02 | 0.196 |
| Male sex | 62 (50) | 14 (45.2) | 16 (51.6) | 14 (45.2) | 18 (58.1) | 0.701 |
| DM | 58 (46.8) | 17 (54.4) | 16 (51.6) | 9 (29) | 16 (27.6) | 0.150 |
| HTN | 87 (70.2) | 24 (77.4) | 21(67.7) | 21 (67.7) | 21 (67.7) | 0.792 |
| CKD | 61 (49.2) | 21 (67.7) | 12 (38.7) | 17 (54.8) | 11 (35.5) | 0.039 |
| Severity of AKI | 0.317 | |||||
| KDIGO stage 1 | 45 (36.3) | 16 (51.6) | 12 (38.7) | 9 (29.0) | 8 (25.8) | |
| KDIGO stage 2 | 37 (29.8) | 9 (25.8) | 7 (9.3) | 12 (38.7) | 10 (32.3) | |
| KDIGO stage 3 | 42 (33.9) | 7 (22.6) | 12 (38.7) | 10 (32.3) | 13 (41.9) | |
| Baseline serum Cr, mg/dL | 1.21 ± 0.46 | 1.44 ± 0.66 | 1.22 ± 0.41 | 1.08 ± 0.29 | 1.08 ± 0.41 | 0.994 |
| Admission serum Cr, mg/dL | 3.00 ± 1.95 | 2.84 ± 1.25 | 2.91 ± 1.51 | 2.94 ± 1.84 | 3.32 ± 2.86 | 0.994 |
| Baseline eGFR, mL/min/1.73 m2 | 61.14 ± 25.53 | 59.17 ± 32.91 | 62.22 ± 26.97 | 58.64 ± 17.32 | 64.52 ± 22.68 | 0.870 |
| Urine TIMP-2 at discharge, ng/mL | 3.40 ± 5.97 | 1.65 ± 1.90 | 2.47 ± 2.70 | 2.84 ± 2.63 | 7.27 ± 11.24 | 0.008 |
| Urine IGFBP7 at discharge, ng/mL | 13.29 ± 14.45 | 14.91 ± 25.21 | 12.18 ± 7.76 | 11.40 ± 5.22 | 14.65 ± 13.06 | 0.824 |
| Causes of AKI | 0.760 | |||||
| Postrenal | 4 (3.2) | 2 (6.5) | 2 (6.5) | 0 | 0 | |
| Prerenal | 56 (45.2) | 14 (45.2) | 16 (51.6) | 15 (48.4) | 11 (35.5) | |
| Intrinsic | 59 (47.6) | 13 (41.9) | 13 (41.9) | 15 (48.4) | 18 (58.1) | |
| Unknown | 5 (4.0) | 2 (6.5) | 0 | 1 (3.2) | 2 (6.5) |
Values are presented as mean ± SD or number (%).
TIMP-2, tissue inhibitor of metalloproteinase-2; IGFBP7, insulin-like growth factor-binding protein 7; DM, diabetes mellitus; HTN, hypertension; CKD, chronic kidney disease; AKI, acute kidney injury; KDIGO, Kidney Disease Improving Global Outcomes; Cr, creatinine; eGFR, estimate glomerular filtration rate.