Table 3.

Univariate and multivariate analysis of factors associated with the survival of all patients with intrahepatic cholangiocarcinoma

Variable	Number	Median survival	Univariate analysis p value	Multivariate analysis
				HR (95% CI)	p value
Age, yr
< 65	55	302
≥ 65	66	183.5	0.005	1.415 (0.856–2.339)	0.176
Hepatitis
No	98	213
Hepatitis B	19	302	0.166
Hepatitis C	4	128.5	0.603
Hepatitis B or C
No	98	213
Yes	23	280	0.279
CTP score
< 7	100	216.5
≥ 7	21	139	0.570
Albumin, g/dL
< 3.5	40	119.5
≥ 3.5	81	268	0.025	0.875 (0.522–1.467)	0.612
Bilirubin, mg/dL
< 3.0	111	217
≥ 3.0	10	71	0.209
CA 19–9, ng/mL
< 100	60	291
≥ 100	55	180	< 0.001	2.378 (1.499–3.773)	< 0.001
T stage
T1–T3	77	338
T4	44	124	< 0.001	1.811 (1.022–3.210)	0.042
Lymph node
Negative	45	386
Positive	76	159	< 0.001	1.756 (1.018–3.027)	0.043
Distant metastasis
No	76	291
Yes	45	122	< 0.001	1.219 (0.729–2.038)	0.449
Adjuvant chemotherapy
Yes	15	612	0.004	0.615 (0.230–1.642)	0.322
No	105	194
Palliative chemotherapy
Yes	60	248.5	0.713
No	60	194.5
Curative surgery
Yes	36	538	< 0.001	0.426 (0.194–0.934)	0.033
No	84	144.5
Tumor size, cm
< 5	20	538
≥ 5	12	561.5	0.518
Surgical procedure
Major resection	16	406	0.282
Minor resection	16	612
Resection margin
Negative	26	406
Positive	7	612	0.959
Tumor differentiation
Well or moderate	22	579.6
Poor or un-differentiation	10	1242.3	0.252
Perineural invasion
Yes	4	962	0.726
No	29	518
Portal vein invasion
Yes	5	280	0.379
No	27	612
Microvascular invasion
Yes	13	377	0.150
No	19	588
Histologic cirrhosis
Yes	4	744.5	0.687
No	29	518

Median survival is expressed in days.

HR, hazard ratio; CI, confidence interval; CTP, Child-Turcotte-Pugh; CA 19-9, carbohydrate antigen 19-9.