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. 2020 Apr 29;35(3):498–513. doi: 10.3904/kjim.2020.105

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Copyright © 2020 The Korean Association of Internal Medicine

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — Patient-centered outcomes in major randomized controlled trials and their sub-analyses of sacubitril/valsartan. CV, cardiovascular; HF, heart failure; PARADIGM-HF, Prospective comparison of Angiotensin Receptor-Neprilysin Inhibitor (ARNI) with ACEI to Determine Impact on Global Mortality and morbidity in Heart Failure; HFrEF, heart failure with reduced ejection fraction; PIONEER-HF, Comparison of Sacubitril-Valsartan versus Enalapril on Effect on NT-proBNP in Patients Stabilized from an Acute Heart Failure Episode; LVAD, left ventricular assist device; HT, heart transplantation; PARAGON-HF, Prospective Comparison of ARNI with ARB Global Outcomes in HF With Preserved Ejection Fraction; HFpEF, heart failure with preserved ejection fraction. ^aPrimary endpoint. ^bAdjudicated outcome by a blinded clinical event committee. ^cRate ratio.