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. 2020 May 11;11(5):348. doi: 10.1038/s41419-020-2525-x

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Left: tRNA Am levels in NSCLC tumors were lower than that in normal tissues; right: FTSJ1 was downregulated in NSCLC tumor tissues compared with that in normal tissues. b Total ion chromatogram of Am detected by HPLC-MS assay. c Expression levels of FTSJ1 in NSCLC cells (H226, A549, and PC9) were significantly lower than that in normal bronchial epithelial cells (BEAS-2B). d Left: transfection of FTSJ1 into NSCLC cells resulted in increased expression of FTSJ1; right: overexpression of FTSJ1 led to increased level of tRNA Am modification in NSCLC cells. e Left: knockdown of FTSJ1 inhibited FTSJ1 expression in NSCLC cells; right: silencing of FTSJ1 reduced Am modification levels in NSCLC cells. *P < 0.05; **P < 0.01.