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. 2020 May 11;5:38. doi: 10.1038/s41541-020-0187-4

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Body weight prior to challenge was set at 100% and percentage weight loss was subtracted from baseline a. Presented are the individual data and lines connecting the averages: placebo (black squares), split vaccines alone (45 µg HA—blue circles, 15 µg HA—red triangles) or SWE-adjuvanted split vaccines (15 µg HA—green open circles, 7.5 µg HA—purple diamonds). Body temperature was recorded every 30 min by transponders that were placed in the intraperitoneal cavity. To analyze fever development, the temperature difference compared with baseline was calculated and the average ΔT per group was plotted. The colored dotted lines indicate the standard deviation. The several sharp decreases in temperature are a result of sedation required for sampling and challenge. Color coding is the same as for the body weight graph. b.1 placebo; b.2 45 µg split; b.3 15 µg split; b.4 15 µg split-SWE; b5 7.5 µg split-SWE. Vertical dotted lines indicate: a. challenge; b and c. swab collection; d. termination. WMW test: **p < 0.01.