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. 2020 May 11;11:2350. doi: 10.1038/s41467-020-16170-3

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Frequency of RB1 E864* mutation detected by ddPCR in pre-treatment cell populations and after selection with JQ1, palbociclib, and paclitaxel, alone and in combinations. Source data are provided as a Source Data file. b Western blots show pRB levels in wild-type and RB1-deleted SUM159 cells. c Levels of synergism between JQ1 and palbociclib in wild-type and RB1-deleted cells at various doses. Each point represents the combination index (CI) for one pair of concentrations, averaged over eight replicates. CI = 1 additive, CI < 1 synergistic, and CI > 1 antagonistic. Source data are provided as a Source Data file. d Growth curves of wild-type and RB1-deleted cells treated with DMSO or 77 nM JQ1 + 611 nM palbociclib. Data are represented as mean ± SD, n = 68 for DMSO and n = 8 for JQ1 + palbociclib, one-way ANOVA followed by Sidak’s multiple comparisons test. Source data are provided as a Source Data file.