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. 2020 May 11;11(5):341. doi: 10.1038/s41419-020-2529-6

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Transwell migration assay showing increase of cell migration in HCT116 overexpressing TAGLN in response to 10% FBS attractant. Effects of TAGLN depletion on HT-29 (b) and RKO (c) cell migration using transwell migration system. d Effect of exogenous TGFβ (10 ng/mL) and TGFβ inhibition using SB431542 (10 µM) on RKO cell migration using the transwell migration system. Effects of TAGLN depletion (e) and exogenous TGFβ (10 ng/mL) and TGFβ inhibition using SB431542 (10 µM) (f) on RKO cell migration using wound-healing assay. Time-lapse microscopy was conducted using EVOS FL Auto Cell Imaging System where images were taken every 30 min over 4 days. g Subcutaneous tumor formation of control (siControl) and TAGLN-depleted (siTAGLN) RKO cells in nude mice. Data are presented as mean (tumor volume) ± S.E., n = 5 per group. Representative tumors at the end of experiment is shown (upper panel).