Fig. 7. Molecular signature of TAGLN^high COAD.

a Heat map clustering of TAGLN^high (m = 296) and TAGLN^low (n = 296) COAD. Samples were stratified into TAGLN^high and TAGLN^low based on median TAGLN expression. Each row represents expression level of an mRNA (log2). mRNA expression level in a single sample is depicted according to the color scale. b Principal component analysis (PCA) for TAGLN^high (m = 296) and TAGLN^low COAD. c Bar-graph depicting the top thirty significantly activated upstream regulator networks in TAGLN^high vs TAGLN^low COAD. Activation Z-score is indicated on the x-axis. d Illustration of the TGFβ1 mechanistic network.