Figure 1.

Current genome editing technology platforms can be divided into two main groups: specific endonuclease (SEN)‐based (right) and nuclease‐independent (left) platforms. The three main types of SEN‐based genome editing platforms are the transcription activator‐like effector nuclease (TALEN), zinc finger nuclease (ZFN), and clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR‐associated protein 9 (Cas9) systems. The principal SEN‐free gene editing platforms use recombinant adeno‐associated virus (rAAV) vectors and triplex‐forming oligonucleotides (TFOs)