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. 2020 May 5;8:296. doi: 10.3389/fcell.2020.00296

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Copyright © 2020 Ramírez-Bajo, Martín-Ramírez, Bruno, Pasquino, Banon-Maneus, Rovira, Moya-Rull, Lazo-Rodriguez, Campistol, Camussi and Diekmann.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Impact of cell therapies on the expression of renal fibrosis markers, PAI-1, TIMP-1, and IFN-γ in CsA-induced nephrotoxicity. The quantification of gene expression was evaluated by real-time PCR using the 2−ΔΔCt method and normalizing with HPRT as the endogenous control. (A) Preventive treatment. (B) Curative treatment. (n = 6 per group). * Significantly different compared to CsA group (*P < 0.05; **P < 0.01; ***P < 0.001). Data are expressed as mean ± SEM. Unpaired Student’s t-test was used for statistical analysis.