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. 2020 May 5;8:296. doi: 10.3389/fcell.2020.00296

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Copyright © 2020 Ramírez-Bajo, Martín-Ramírez, Bruno, Pasquino, Banon-Maneus, Rovira, Moya-Rull, Lazo-Rodriguez, Campistol, Camussi and Diekmann.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Histological changes in renal sections stained with PAS from mice with CsA-induced nephrotoxicity with or without different regimens of cell therapy (BM-MSC, EVs and dCM). (A) Representative micrographs of kidney histology of healthy C57BL/6 mice treated with castor oil as control group (A1) and mice treated with CsA (75mg/kg daily) indicating tubular vacuolization (red arrow), hyaline casts (black arrow) and cysts (asterisks) (A2). (B) Preventive treatments of CsA nephrotoxicity with BM-MSC (B1), EVs (B3), and dCM (B5); curative treatments of CsA nephrotoxicity with BM-MSC (B2), EVs (B4), and dCM (B6). PAS staining. Original Magnification: x200.