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. 2020 May 5;11:794. doi: 10.3389/fimmu.2020.00794

FIGURE 4.

FIGURE 4

Kinetic follow-up of protease/C1-INH complexes during an angioedematous attack. Kinetics of total C1-INH concentration (C1-INHt), active C1-INH concentration (C1-INHa) and concentrations of C1r-, C1s-, MASP- 1-, MASP- 2-, kallikrein-, FXIIa-, FXIa-, and thrombin/C1-INH, complexes during an HAE attack of a type I C1-INH-HAE patient. Severity of angioedematous symptoms were assessed by the patient in a visual analog scale (VAS, 0–100%). Symptom-free periods are marked with green, prodromal phase with yellow and HAE attack phase with orange colors.