Table 2.
Ten key genes identified by global signal transduction network analysis.
| Gene symbol | Offical full name | Style | Degree | Indegree | Outdegree | p-value | Fold change |
|---|---|---|---|---|---|---|---|
| Pi3k | phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma | up | 30 | 24 | 6 | 0.003 | 1.79 |
| Jak2 | Janus kinase 2 | up | 26 | 23 | 3 | 0.0008 | 1.75 |
| Gng7 | G protein subunit gamma 7 | down | 18 | 14 | 4 | 0.002 | −1.65 |
| Jun | Jun proto-oncogene, AP-1 transcription factor subunit | up | 18 | 2 | 16 | 0.0005 | 1.89 |
| IL6 | interleukin 6 | up | 16 | 5 | 11 | 0.001 | 2.24 |
| Met | MET proto-oncogene, receptor tyrosine kinase | up | 13 | 10 | 3 | 7.321E-0.5 | 2.34 |
| Pdgfra | platelet derived growth factor receptor alpha | up | 13 | 10 | 3 | 0.0006 | 1.65 |
| Camk2b | calcium/calmodulin-dependent protein kinase II beta | down | 12 | 0 | 12 | 0.0006 | −1.51 |
| Ptgs2 | prostaglandin-endoperoxide synthase 2 | up | 12 | 10 | 2 | 0.014 | 2.51 |
| Sdc1 | syndecan 1 | up | 12 | 12 | 0 | 8.327E-0.5 | 1.96 |
P-value was corrected by FDR.