Figure 8. The most potent and least potent compounds in each series. (A) Scaffold A: Two most potent compounds 1a, 3a and the least potent compounds 8a involved in BIC1 (circle color) and F06[N-O] (red color bonds) descriptors; (B) Scaffold B: The most potent compounds 1b, 2b and the least potent compound 3b (red bond indicate carbon linker).
