Table 1.

Monitoring of clinical and laboratory in patients with TAM.

Parameter	Day +61	Day +68	Day +75	Day +120	Normal ranges*
Clinical symptoms	-Neurologic impairment -Fever	-Anuria -Neurologic impairment -Moderate arterial hypertension -Fever	-Bleeding -Severe arterial hypertension	-Moderate arterial hypertension
Treatment	Tacrolimus	RRT and defibrotide initiation	RRT and defibrotide stop
Blood tests
Creatinine, μmol/L	50.9	472	150	75.5	<56
Urea, mmol/L	3.4	19	10	3.7	2.5–6
Lactate dehydrogenase ME/L	388	577	703	305	<332
Haptoglobin, g/L	0.14	0.44		0.05	0.3–2
Hemoglobin, g/L	106	71	105**	92**	115–138
Platelets, × 109/L	152	104	75**	133	150–400
Shistocytes, %0	0	2		2	<2.7
Coombs test		Negative		Negative
Tacrolimus, ng/mL	5.9	0.5
Coagulation tests
Fibrinogen, g/L		3.06	4.66
Prothrombin time, %		89	87		70–120
Activated partial thromboplastin time, s		30.1	12.9		25.1–36.5
Thrombin time, s		23.7	24.3		15.8–24.9
C3, g/L			0.74		0.66–1.1
Urinalysis
Urine total protein, g/L	1	5		0.2	<0.5

^*Our laboratory normal value for age.

^**With transfusion support.