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. 2020 May 5;12:113. doi: 10.3389/fnagi.2020.00113

FIGURE 2.

FIGURE 2

Body weight changes in early- and late-MA female 3xTg-AD mice. Body weight was measured weekly in (A) early-MA females and (F) late-MA females. Estradiol-filled capsules were administered after 8 weeks of diet. The percent weight change was calculated over the first 8 weeks of diet, before capsule implant, in (B) early-MA and (G) late-MA mice. Change in body weight was also measured during the second 8 weeks, to assess the effect of E2 treatment, in (C) early-MA and (H) late-MA female mice. Retroperitoneal and visceral fat pads were weighed and normalized to body weight in (D,E) early-MA and (I,J) late-MA mice, respectively. Data from early-MA (upper panels) and late-MA (lower panels) is separated by a dotted line. Significance is p < 0.05. D = significant main effect of diet; H = significant main effect of hormone treatment; X = significant interaction between diet and hormone; d = significant post hoc effect between diets, but within hormone treatment; h = significant post hoc effect between hormone treatment, within diet.