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. 2020 May 5;12:113. doi: 10.3389/fnagi.2020.00113

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Copyright © 2020 Christensen, Liu and Pike.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Metabolic effects in early- and late-MA female 3xTg-AD mice. Fasting glucose was measured at weeks 0, 8, and 15. Fasting glucose levels for (A) early-MA and (E) late-MA mice. An oral glucose tolerance test was administered at week 15 in (B) early-MA and (F) late-MA females. Fasting leptin was measured from the plasma collected at week 16 in (C) early-MA and (G) late-MA mice. The area under the curve (AUC) was calculated from the glucose tolerance test in (D) early-MA and (H) late-MA mice. Significance is p < 0.05. D = significant main effect of diet; H = significant main effect of hormone treatment; X = significant interaction between diet and hormone; d = significant post hoc effect between diets, but within hormone treatment; h = significant post hoc effect between hormone treatment, within diet.