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. 2020 May 5;12:113. doi: 10.3389/fnagi.2020.00113

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Copyright © 2020 Christensen, Liu and Pike.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Behavior and neurogenesis in early- and late-MA female 3xTg-AD mice. Correct responses in the spontaneous alternation test were measured in (A) early-MA and (C) late-MA 3xTg-AD females at week 14. Doublecortin-positive cells were counted in the dentate gyrus of the hippocampus at week 16 in (B) early-MA and (D) late-MA mice to measure neurogenesis. Significance is p < 0.05. H = significant main effect of hormone treatment; h = significant post hoc effect between hormone treatment, within diet.