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. 2020 May 5;8:366. doi: 10.3389/fbioe.2020.00366

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Copyright © 2020 Lopa, Piraino, Talò, Mainardi, Bersini, Pierro, Zagra, Rasponi and Moretti.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Cell trapping model. (A) All the experimental conditions included in the model are represented as 2D matrices. (B–E) Interaction plots describing the relation between cell concentration and flow rate or seeding time. Lines describe the variation of the number of trapped cells in correspondence of the minimum and maximum values of the variable indicated in the right y-axis for increasing values of the variable indicating in the x-axis. (F) Schematic of the working principle of the predictive model. (G) Comparison between the numbers of trapped cells obtained experimentally and predicted by the model for the following parameters: 10M cells/ml, 2.5 μl/min, 60 min. (H) Correlation plot describing the correlation between the number of trapped cells experimentally measured and the number predicted by the model.