TABLE 1.

Chitosan drug delivery systems for brain targeting reported in the last 5 years.

Drug	Presentation	Application	Administration route	References
Pentamidine	Chitosan coated niosomes	Parkinson’s disease	Intranasal	Rinaldi et al., 2019
Methotrexate	Chitosan hydrogel nanoparticles	Antineoplastic agent	Intravenous	Pourtalebi-Jahromi et al., 2019
Carbamazepine	Chitosan coated lipid nanoparticle formulation	Epilepsy	Oral	Ana et al., 2019
Rotigotine	Chitosan nanoparticles	Parkinson’s disease	Intranasal	Tzeyung et al., 2019
Doxorubicin/erlotinib	Chitosan liposomal nanoparticles	Glioblastoma	–	Lakkadwala and Singh, 2019
Docetaxel	TMC hydrogel	Glioblastoma	Intracranial injection	Turabee et al., 2019
Risperidone	Chitosan lipid nanoparticle	Schizophrenia	Intranasal	Qureshi et al., 2019
Pramipexole dihydrochloride	Chitosan nanoparticles	Parkinson’s Disease	Intranasal	Raj et al., 2018
Galantamine	Chitosan nanoparticles	Amnesia/Alzheimer	Intranasal	Sunena et al., 2019
Selegiline	Chitosan nanoparticles	Parkinson Disease	Intranasal	Sridhar et al., 2018
Temozolomide	Nano lipid chitosan hydrogel	Antineoplastic agent	Intranasal	Khan et al., 2018
Cyclovirobuxine d	Chitosan nanoparticles	Cerebrovascular disease	Intranasal	Wei et al., 2018
Diazepam	Chitosan mucoadhesive microemulsion	Status epilepticus	Intranasal	Ramreddy and Janapareddi, 2019
Tapentadol hydrochloride	Chitosan nanoparticles	Pain	Intranasal	Javia and Thakkar, 2017
Rivastigmine hydrogen tartrate	Chitosan mucoadhesive microemulsion	Cholinesterase inhibitor	Intranasal	Shah et al., 2018
Ribavirin	Chitosan microparticle agglomerates	Viral infection	Intranasal	Giuliani et al., 2018
Huperzine A	Lactoferrin-conjugated TMC surface-modified PLGA nanoparticles	Alzheimer’s disease	Intranasal	Meng et al., 2018
Ropinirolle-detran sulfate	Chitosan mucoadhesive neuro-nanoemulsion	Parkinson’s disease	Intranasal	Pardeshi and Belgamwar, 2018
Zolmitriptan	Chitosan mucoadhesive nanoemulsion	Migraine	Intranasal	Abdou et al., 2017
Desvenlafaxine	PLGA-chitosan nanoparticles	Depression	Intranasal	Tong et al., 2017
Selegiline hydrochloride	Thiolated chitosan nanoparticles	Depression	Intranasal	Singh et al., 2016
Quetiapine fumarate	Chitosan microemulsion	Schizophrenia	Intranasal	Shah et al., 2016
Rasagiline	Chitosan glutamate nanoparticles	Parkinson’s disease	Intranasal	Mittal et al., 2016
Ropinirole hydrochloride	Chitosan mucoadhesive nanoparticles	Parkinson’s disease	Intranasal	Jafarieh et al., 2015
Buspirone hydrochloride	Thiolated chitosan nanoparticles	General anxiety disorder	Intranasal	Bari et al., 2015
Doxepin hydrochloride	Chitosan-glycerophosphate-PEG thermoreversible biogels	Depression	Intranasal	Naik and Nair, 2014
Buspirone	Chitosan mucoadhesive microemulsion	General anxiety disorder	Intranasal	Bshara et al., 2014
Donepezil	Chitosan nanosuspension	Alzheimer disease	Intranasal	Bhavna et al., 2014
Levodopa	Chitosan nanoparticles	Parkinson’s Disease	Intranasal	Sharma et al., 2014