TABLE 2.
Chitosan-based biomaterials for implantation in CNS or neural cell culture reported in the last 5 years.
| Composition | Presentation | Application | Model | References |
| Collagen and chitosan | 3D printed scaffolds | Implantation as therapeutic in SCI | Rat | Sun et al., 2019 |
| Chitosan-multiwalled carbon nanotubes | Nanomaterial scaffold | Culture for implantation | In vitro | Gupta et al., 2019 |
| Polyaniline-chloride, chitosan, and NGF | Microporous scaffolds | Tissue engineering | In vitro | Abasi et al., 2019 |
| Gelatin and glycine-functionalized polypyrrole-coated poly(vinyl alcohol) with chitosan | Scaffold | Culture for implantation | Mice | Naghavi-Alhosseini et al., 2019 |
| PEDOT, chitosan and gelatin | Scaffold | Substrate for NSC research and neural tissue engineering | In vitro | Wang S. et al., 2018 |
| Chitosan and PDGF | Scaffold and microspheres | Tissue-engineered spinal cord grafts | In vitro | Chen et al., 2018 |
| Chitosan | Scaffold | Implantation in SCI | Rat | Yao et al., 2018 |
| NT-3 – chitosan | Tube | Implantation in SCI | Monkey | Rao et al., 2018 |
| PEDOT and CMC | Conductive polymer layer/Hydrogel | Neural tissue engineering | In vitro | Xu et al., 2018 |
| Chitosan and heparin | Scaffold | Culture of stem cells for implantation | In vitro | Moore et al., 2018 |
| NT-3 – chitosan | Chitosan particles | Implantation in TBI | Rat | Hao P. et al., 2017 |
| Chitosan | Fragmented physical hydrogel suspensión | Implantation in SCI | Rat | Chedly et al., 2017 |
| Chitosan lactate | Hydrogel | Implantation in SCI | Rat | Nawrotek et al., 2017 |
| Polyacrylamide, chitosan scaffold, and PLGA nanoparticles | Inverted colloidal crystal scaffold | Culture for iPS differentiation into neurons and implantation for nerve regeneration | In vitro | Kuo and Chen, 2017 |
| Alginate, CMC, and agarose | Porous 3D scaffold | Tissue engineering | In vitro | Gu et al., 2016 |
| Chitosan and polylactic acid | Nanofibrous scaffold | Culture of stem cells for tissue engineering and cell-based therapy | In vitro | Ebrahimi-Barough et al., 2015 |
| NT-3 – chitosan | Tube | Implantation in SCI | Rat | Duan et al., 2015 |
| Chitosan | Scaffold | Culture of stem cells for differentiation and implantation in TBI | In vitro | Feng et al., 2014 |