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. 2020 May 5;11:525. doi: 10.3389/fphar.2020.00525

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Copyright © 2020 Yang, Zhang, Yang, Ruan, Luo, Long and Tang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of CLG on body mass, the paw withdrawal latency to heat stimulation (PWL) and the paw withdrawal threshold to mechanical stimulation (PWT) in the CIBP rat model. (A) Growth curve of body weight of rats in each group (n=6). (B) The PWL of rats in each group (n = 6). (C) The PWT of rats in each group (n=6). In the model group, the PWL and PWT were decreased on the 7th, 14th, and 21st day following surgery, and no significant changes were noted in the sham group. On day 21 of administration, and 7 days following administration, the PWL and PWT were increased in the CLGH, CLGM, CLGL, and QMD groups and the model control group indicated a continuous decrease, whereas the sham group indicated no significant change.