Table 4.
Parameter estimates and bootstrap results of the final model.
| Parameter | Final model | Bootstrap analysis | Bias (%) |
|||
|---|---|---|---|---|---|---|
| Estimate | SE(%) | 2.5th percentile |
Median Estimate |
97.5th percentile |
||
| θV1(L) | 2.31 | 13.31 | 1.51 | 2.16 | 2.74 | −6.49 |
| θV2(L) | 16.19 | 3.10 | 12.34 | 15.25 | 18.22 | −5.81 |
| θCL(L/h) | 0.13 | 21.51 | 0.04 | 0.13 | 0.23 | 0 |
| θQ(L/h) | 0.23 | 13.13 | 0.10 | 0.24 | 0.37 | 4.35 |
| θ1 | 0.14 | 30.69 | 0.02 | 0.15 | 0.29 | 7.14 |
| θ2 | 0.19 | 30.68 | 0.02 | 0.20 | 0.41 | 5.26 |
| θ3 | 0.74 | 29.67 | 0.51 | 0.81 | 1.85 | 1.46 |
| θ4 | 0.60 | 30.49 | 0.12 | 0.58 | 1.01 | −3.33 |
| Inter-individual | ||||||
| ωV1(%) | 105.43 | 5.95 | 88.84 | 104.52 | 120.20 | 0.86 |
| ωV2(%) | 19.58 | 6.23 | 17.46 | 20.40 | 23.34 | 4.19 |
| ωCL(%) | 44.67 | 5.88 | 38.44 | 44.32 | 50.21 | −0.78 |
| ωQ(%) | 42.86 | 5.95 | 38.81 | 46.65 | 54.49 | 8.84 |
| ηV1-shrinkage(%) | 29.81 | |||||
| ηV2-shrinkage(%) | 67.67 | |||||
| ηCL-shrinkage(%) | 29.23 | – | – | – | – | – |
| ηQ-shrinkage(%) | 47.96 | |||||
| Residual variability | ||||||
| σ | 0.46 | 30.20 | 0.19 | 0.48 | 0.77 | 4.35 |
| ϵ-shrinkage(%) | 19.71 | – | – | – | – | – |
θV1, typical value of central volume of distribution; θV2, typical value of peripheral volume of distribution; θCL, typical value of apparent clearance; θQ, typical value of inter-compartment clearance; θ1, exponent for lnWT as covariate for V1; θ2, exponent for WT as covariate for V2; θ3, exponent for WT as covariate for CL; θ4, exponent for eGFR as covariate for CL; ωV1, square root of inter-individual variance for V1; ωV2, square root of inter-individual variance for V2; ωCL, square root of inter-individual variance for CL; ωQ, square root of inter-individual variance for Q; σ, residual variability for power error; SE(%), percent standard error.