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. 2020 May 5;11:730. doi: 10.3389/fimmu.2020.00730

FIGURE 2.

FIGURE 2

IL-1Ra deficiency upregulates the level of inflammatory factors in joints of an MIA-induced murine model. BALB/c and IL-1Ra KO mice were injected intra-articularly with 0.6 mg MIA in the right knee. At 3 weeks after the MIA injection, sections of articular tissue from MIA-injected mice and untreated BALB/c and IL-1Ra KO mice were immunostained for IL-1β (A), IL-6 (B), IL-17 (C), phosphorylated STAT3 (S727) (D), MCP-1 (E), and CCR2 (F). Representative histological features are shown (original magnification 400×). The results are quantified as the means ± SDs for number of antibody-positive cells in three animals per group. **P < 0.01, ***P < 0.001. BALB/c vs. IL-1Ra KO. MIA-injected BALB/c group vs. MIA-injected IL-1Ra KO group (One-way ANOVA followed by Bonferroni post hoc test).