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. 2020 May 5;11:730. doi: 10.3389/fimmu.2020.00730

FIGURE 4.

FIGURE 4

IL-17 deficiency ameliorates pain and cartilage damage. IL-1Ra KO mice and IL-17-deficient IL-1Ra double-deficient mice (DKO) were injected with 0.6 mg MIA in the right knee. (A) Behavioral tests of secondary tactile allodynia in MIA-injected IL-1Ra KO mice and IL-1Ra and IL-17 double-deficient mice were evaluated using a dynamic plantar esthesiometer (IL-1Ra KO MIA n = 3, DKO MIA n = 4). Experimental mechanical pain was analyzed using the PWT. (B) At 4 weeks after the MIA injection, sections of articular tissue from mice were stained with Safranin O and we evaluated the severity of Mankin and OARSI scores. Representative histological features are shown (original magnification 200×). Three independent experiments were performed. Data are means ± SDs. **P < 0.001, ***P < 0.001 MIA-injected IL-1Ra KO mice group vs. MIA-injected DKO [2-tailed t-test (B)].