. 2020 May 12;115(4):36. doi: 10.1007/s00395-020-0795-1

Table 2.

Leukocyte counts and inflammatory markers in patients receiving CAP-1002

	Patient 1	Patient 2	Patient 3	Patient 4	Patient 5	Patient 6
WBC (× 1000/ul)	Day 0: 12.87 Day 1: 13.84 Day 2: 12,99 Day 3: 12.85 Day 4: 10.01 Day 5: 8.08 Day 6: 5.64 Day 7: 6.79	Day 0: 5.8 Day 1: 8.4 Day 2: 6.39 Day 3: 9.86 Day 5: 8.02 Day 7: 5.63	Day 0: 10.17 Day 1: 10.35 Day 2: 8.63 Day 3: 9.34 Day 6: 7.50 Day 9: 4.34	Day 0: 13.79 Day 1: 13.50 Day 2: 11.76 Day 4: 13.07 Day 5: 11.59 Day 6: 14.51(pre 2nd dose) Day 7: 15.67 (post 2nd dose) Day 8: 14.67 Day 18: 23.13	Day 0: 6.38 Day 1: 7.24 Day 2: 9.79 Day 3 10.45 Day 4: 9.75 Day 5: 8.15 Day 6: 7.2 Day 10: 4.69	Day 0: 4.41 Day 1: 8.32 Day 2: 7.84 Day 3: 9.03 Day 4: 10.78 Day 5: 13.69
Lymphocytes (× 1000/ul)	Day 0: 0.26 Day 1: 0.55 Day 2: 0.65 Day 3: 0.39 Day 5: 0.73 Day 6: 1.02	Day 0: 1.40 Day 1: 1.1 Day 2: 1.29 Day 3 1.09	Day 0: 0.31 Day 1: 0.41 Day 2: 0.86 Day 3: 0.37 Day 6: 0.55 Day 9: 0.53	Day 0: 0.82 Day 1: 1.35 Day 2: 0.59 Day 3: 0.52 Day 4: 0.46 Day 5: 0.67 Day 6: 0. 43 (pre 2nd dose) Day 7: 0.63 (post 2nd dose) Day 8: 0.59 Day 18: 0.23	Day 0: 0.33 Day 1: 0.46 Day 2: 0.85 Day 3: 0.91 Day 4: 0.80 Day 5: 0.85 Day 6: 0.79 Day 10: 0.66	Day 0: 0.54 Day 1: 0.49 Day 2: 0.48 Day 3: 0.45 Day 4: 0.48 Day 5: 0.49
C-reactive protein (mg/l)	Day 0: 31.9 Day 1: 18.8 Day 3: 19.9 Day 7: 32.3 (pre 2nd dose) Day 9: 16.0 (post 2nd dose)	Day 0: 15.2 Day 2: 6.1	Day 0: 19.4 Day 1: 15.2 Day 2: 18.2 Day 3: 15.5 Day 6: 17.0 Day 9: 8.5	Day 0: 2.0 Day 1: 2.4 Day 2: 3.2 Day 3: 6.9 Day 4: 4.0 Day 5: 0.5 Day 6: 0.3 (pre 2nd dose) Day 7: 0.2 (post 2nd dose) Day 8: 0.3 Day 18: 54.6	Day 0: 54.6 Day 1: 27.5 Day 3: 7.4 Day 5: 3.6 Day 6: 2.6 Day 10: 1.0	Day 0: 80.3 Day 1: 14.2 Day 2: 8.6 Day 3: 13.3 Day 4: 17.9 Day 5: 44.6
Ferritin (ng/ml)	Day 0: 774.52 Day 1: 755 Day 2: 586.26 Day 7: 522.76 (pre 2nd dose) Day 9: 389.45 (post 2nd dose)	Day 0: 2991.52 Day 2: 1457.84	Day 0: 605.43 Day 1: 584.26 Day 6: 695.76 Day 9: 1029.90	Day 0: 866.81 Day 1: 615.84 Day 2: 445.95 Day 4: 432.93 Day 5: 455.5 Day 6: 466.05 (pre 2nd dose) Day 7: 408.5 (post 2nd dose) Day 8: 344.7 Day 11: 252.89	Day 0: 1281.97 Day 1: 1090.98 Day 2: 1,189.54 Day 3: 1491.9 Day 4: 2266.0 Day 5: 1785.3 Day 6: 1349.8 Day 10: 912.55	Day 0: 1096.83 Day 1: 849.10 Day 2: 798.58 Day 3: 679.62 Day 4: 634.50 Day 5: 688.51
IL-6 (pg/ml)	Day 0: 216.7 Day 1: 124.3 Day 2: 44.2 Day 7: 4.0 (pre 2nd dose) Day 9: < 3.2 (post 2nd dose)	Day 0: 79.8 Day 1: 90.7 Day 2: 267.2	Day 0: 421.5 Day 1: 678.6 Day 6: 52.7 Day 9: 7.9	Day 0: 348.3 Day 1: 482.3 Day 3: 185.2 Day 5: 14.9 Day 6: 7.1 (pre 2nd dose) Day 7: 8 (post 2nd dose) Day 11: < 3.2	Day 0: 1,006.9 Day 1: 588.7 Day 3: 75.7 Day 5: 102.4 Day 10: 77.7	Day 0: 594.7 Day 1:900.5 Day 3:2573.9 Day 5: 2381.4
IL-1α (pg/ml)	Day 0: < 3.9 Day 1: < 3.9 Day 2: < 3.9	Day 0: < 3.9 Day 2: < 3.9	Day 0: – Day 1: – Day 6: –	Day 0: < 3.9 Day 1: < 3.9 Day 3: < 3.9 Day 5: < 3.9	Day 0: < 3.9 Day 1: < 3.9 Day 3: < 3.9	Day 0: – Day 1: – Day 3: – Day 5: –
IL-1β (pg/ml)	Day 0: < 3.2 Day 1: 4.5 Day 2: < 3.2 Day 7: -NA Day 9: -NA	Day 0: < 3.2 Day 1: < 3.2 Day 2: < 3.2	Day 0: < 3.2 Day 1: < 3.2 Day 6: < 3.2	Day 0: < 3.2 Day 1: < 3.2 Day 3: < 3.2 Day 5: < 3.2	Day 0: < 3.2 Day 1: < 3.2 Day 3: < 3.2 Day 5: < 3.2	Day 0: < 3.2 Day 1: < 3.2 Day 3: < 3.2 Day 5: < 3.2
TNF-α (pg/ml)	Day 0: 7.0 Day 1: 4.5 Day 2: 13.1	Day 0: 14.6 Day 1: – Day 2: 30.1	Day 0: 46.7 Day 1: 30.5 Day 6: 24.3	Day 0: 52.5 Day 1: 55.6 Day 3: 35.9 Day 5: 13.6 Day 7: 29.2 (post 2nd dose) Day 11: 19.6	Day 0: 15.6 Day 1: 20.4 Day 3: 22.8 Day 5: 25.2 Day 10: 16.0	Day 0: 17.9 Day 1: – Day 3: 49.4 Day 5: 22.9
IL-10 (pg/ml)	Day 0: < 3.2 Day 1: < 3.2 Day 2: < 3.2 Day 7: < 3.2 (pre 2nd dose) Day 9: < 3.2 (post 2nd dose)	Day 0: 6.1 Day 1: 3.5 Day 2: 10.3	Day 0: 7.5 Day 1: 4.8 Day 6: < 3.2 Day 9: < 3.2	Day 0: 6.3 Day 1: 7.0 Day 3: 3.3 Day 5: < 3.2 Day 7: 10.2 (post 2nd dose) Day 11: < 3.2	Day 0: 8.6 Day 1: 14.8 Day 3: 9.5 Day 5: 8	Day 0: 11.6 Day 1: 15.1 Day 3: 16.7 Day 5: 14.8

Patient 1

Patient 2

Patient 3

Patient 4

Patient 5

Patient 6

WBC (× 1000/ul)

Day 0: 12.87

Day 1: 13.84

Day 2: 12,99

Day 3: 12.85

Day 4: 10.01

Day 5: 8.08

Day 6: 5.64

Day 7: 6.79

Day 0: 5.8

Day 1: 8.4

Day 2: 6.39

Day 3: 9.86

Day 5: 8.02

Day 7: 5.63

Day 0: 10.17

Day 1: 10.35

Day 2: 8.63

Day 3: 9.34

Day 6: 7.50

Day 9: 4.34

Day 0: 13.79

Day 1: 13.50

Day 2: 11.76

Day 4: 13.07

Day 5: 11.59

Day 6: 14.51(pre 2nd dose)

Day 7: 15.67 (post 2nd dose)

Day 8: 14.67

Day 18: 23.13

Day 0: 6.38

Day 1: 7.24

Day 2: 9.79

Day 3 10.45

Day 4: 9.75

Day 5: 8.15

Day 6: 7.2

Day 10: 4.69

Day 0: 4.41

Day 1: 8.32

Day 2: 7.84

Day 3: 9.03

Day 4: 10.78

Day 5: 13.69

Lymphocytes (× 1000/ul)

Day 0: 0.26

Day 1: 0.55

Day 2: 0.65

Day 3: 0.39

Day 5: 0.73

Day 6: 1.02

Day 0: 1.40

Day 1: 1.1

Day 2: 1.29

Day 3 1.09

Day 0: 0.31

Day 1: 0.41

Day 2: 0.86

Day 3: 0.37

Day 6: 0.55

Day 9: 0.53

Day 0: 0.82

Day 1: 1.35

Day 2: 0.59

Day 3: 0.52

Day 4: 0.46

Day 5: 0.67

Day 6: 0. 43 (pre 2nd dose)

Day 7: 0.63 (post 2nd dose)

Day 8: 0.59

Day 18: 0.23

Day 0: 0.33

Day 1: 0.46

Day 2: 0.85

Day 3: 0.91

Day 4: 0.80

Day 5: 0.85

Day 6: 0.79

Day 10: 0.66

Day 0: 0.54

Day 1: 0.49

Day 2: 0.48

Day 3: 0.45

Day 4: 0.48

Day 5: 0.49

C-reactive protein (mg/l)

Day 0: 31.9

Day 1: 18.8

Day 3: 19.9

Day 7: 32.3 (pre 2nd dose)

Day 9: 16.0 (post 2nd dose)

Day 0: 15.2

Day 2: 6.1

Day 0: 19.4

Day 1: 15.2

Day 2: 18.2

Day 3: 15.5

Day 6: 17.0

Day 9: 8.5

Day 0: 2.0

Day 1: 2.4

Day 2: 3.2

Day 3: 6.9

Day 4: 4.0

Day 5: 0.5

Day 6: 0.3 (pre 2nd dose)

Day 7: 0.2 (post 2nd dose)

Day 8: 0.3

Day 18: 54.6

Day 0: 54.6

Day 1: 27.5

Day 3: 7.4

Day 5: 3.6

Day 6: 2.6

Day 10: 1.0

Day 0: 80.3

Day 1: 14.2

Day 2: 8.6

Day 3: 13.3

Day 4: 17.9

Day 5: 44.6

Ferritin (ng/ml)

Day 0: 774.52

Day 1: 755

Day 2: 586.26

Day 7: 522.76 (pre 2nd dose)

Day 9: 389.45 (post 2nd dose)

Day 0: 2991.52

Day 2: 1457.84

Day 0: 605.43

Day 1: 584.26

Day 6: 695.76

Day 9: 1029.90

Day 0: 866.81

Day 1: 615.84

Day 2: 445.95

Day 4: 432.93

Day 5: 455.5

Day 6: 466.05 (pre 2nd dose)

Day 7: 408.5 (post 2nd dose)

Day 8: 344.7

Day 11: 252.89

Day 0: 1281.97

Day 1: 1090.98

Day 2: 1,189.54

Day 3: 1491.9

Day 4: 2266.0

Day 5: 1785.3

Day 6: 1349.8

Day 10: 912.55

Day 0: 1096.83

Day 1: 849.10

Day 2: 798.58

Day 3: 679.62

Day 4: 634.50

Day 5: 688.51

IL-6 (pg/ml)

Day 0: 216.7

Day 1: 124.3

Day 2: 44.2

Day 7: 4.0 (pre 2nd dose)

Day 9: < 3.2 (post 2nd dose)

Day 0: 79.8

Day 1: 90.7

Day 2: 267.2

Day 0: 421.5

Day 1: 678.6

Day 6: 52.7

Day 9: 7.9

Day 0: 348.3

Day 1: 482.3

Day 3: 185.2

Day 5: 14.9

Day 6: 7.1 (pre 2nd dose)

Day 7: 8 (post 2nd dose)

Day 11: < 3.2

Day 0: 1,006.9

Day 1: 588.7

Day 3: 75.7

Day 5: 102.4

Day 10: 77.7

Day 0: 594.7

Day 1:900.5

Day 3:2573.9

Day 5: 2381.4

IL-1α (pg/ml)

Day 0: < 3.9

Day 1: < 3.9

Day 2: < 3.9

Day 0: < 3.9

Day 2: < 3.9

Day 0: –

Day 1: –

Day 6: –

Day 0: < 3.9

Day 1: < 3.9

Day 3: < 3.9

Day 5: < 3.9

Day 0: < 3.9

Day 1: < 3.9

Day 3: < 3.9

Day 0: –

Day 1: –

Day 3: –

Day 5: –

IL-1β (pg/ml)

Day 0: < 3.2

Day 1: 4.5

Day 2: < 3.2

Day 7: -NA

Day 9: -NA

Day 0: < 3.2

Day 1: < 3.2

Day 2: < 3.2

Day 0: < 3.2

Day 1: < 3.2

Day 6: < 3.2

Day 0: < 3.2

Day 1: < 3.2

Day 3: < 3.2

Day 5: < 3.2

Day 0: < 3.2

Day 1: < 3.2

Day 3: < 3.2

Day 5: < 3.2

Day 0: < 3.2

Day 1: < 3.2

Day 3: < 3.2

Day 5: < 3.2

TNF-α (pg/ml)

Day 0: 7.0

Day 1: 4.5

Day 2: 13.1

Day 0: 14.6

Day 1: –

Day 2: 30.1

Day 0: 46.7

Day 1: 30.5

Day 6: 24.3

Day 0: 52.5

Day 1: 55.6

Day 3: 35.9

Day 5: 13.6

Day 7: 29.2 (post 2nd dose)

Day 11: 19.6

Day 0: 15.6

Day 1: 20.4

Day 3: 22.8

Day 5: 25.2

Day 10: 16.0

Day 0: 17.9

Day 1: –

Day 3: 49.4

Day 5: 22.9

IL-10 (pg/ml)

Day 0: < 3.2

Day 1: < 3.2

Day 2: < 3.2

Day 7: < 3.2 (pre 2nd dose)

Day 9: < 3.2 (post 2nd dose)

Day 0: 6.1

Day 1: 3.5

Day 2: 10.3

Day 0: 7.5

Day 1: 4.8

Day 6: < 3.2

Day 9: < 3.2

Day 0: 6.3

Day 1: 7.0

Day 3: 3.3

Day 5: < 3.2

Day 7: 10.2 (post 2nd dose)

Day 11: < 3.2

Day 0: 8.6

Day 1: 14.8

Day 3: 9.5

Day 5: 8

Day 0: 11.6

Day 1: 15.1

Day 3: 16.7

Day 5: 14.8

Day 0 shows laboratory values prior to the first administration of CAP-1002. Patients 1 and 4 received a second dose of CAP-1002, 7 days after the first infusion