Table 3. Summary of the diagnostic accuracy of GP73, GPC-3, AFP, GP73 + AFP, GPC-3 + AFP, GP73 + GPC-3 + AFP.

Marker	N	Pooled sensitivity (95% CI)	Pooled specificity (95% CI)	PLR (95% CI)	NLR (95% CI)	DOR (95% CI)	AUC (95% CI)
GP73	9	0.77 (0.69–0.83)	0.93 (0.86–0.96)	10.8 (5.2–22.1)	0.25 (0.18–0.34)	43 [17–110]	0.90 (0.87–0.92)
GPC-3	9	0.59 (0.47–0.70)	0.93 (0.89–0.95)	8.3 (5.0–13.7)	0.44 (0.33–0.59)	19 [9–38]	0.89 (0.86–0.91)
AFP	10	0.65 (0.55–0.74)	0.88 (0.84–0.91)	5.4 (4.0–7.3)	0.40 (0.30–0.52)	14 [8–23]	0.88 (0.84–0.90)
GP73 + AFP	8	0.85 (0.77–0.90)	0.86 (0.80–0.91)	6.1 (4.3–8.6)	0.18 (0.12–0.26)	34 [22–54]	0.92 (0.89–0.94)
GPC-3 + AFP	7	0.71 (0.61–0.79)	0.91 (0.81–0.95)	7.5 (4.0–14.0)	0.33 (0.25–0.42)	23 [13–40]	0.85 (0.82–0.88)
GP73 + GPC-3 + AFP	12	0.91 (0.87–0.94)	0.84 (0.77–0.89)	5.8 (4.0–8.4)	0.10 (0.07–0.15)	58 [36–92]	0.95 (0.92–0.96)

GP73, Golgi protein 73; GPC-3, Golgi protein glypican-3; AFP, alpha-fetoprotein; AUC, the area under the curve; DOR, diagnostic odds ratio; NLR, negative likelihood ratio; PLR, positive likelihood ratio.