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. 2020 Apr;8(8):552. doi: 10.21037/atm-20-3263

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2020 Annals of Translational Medicine. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0.

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Survival curves comparing the high and low expression of DKK1 in different types of cancers in the GEPIA database. (A) OS survival curve and (B) PFS survival curve of head and neck squamous cell carcinoma (HNSC) (n=518); high DKK1 expression was correlated with poor prognosis of OS and PFS in HNSC. (C) OS survival curve and (D) PFS survival curve of pancreatic adenocarcinoma (PAAD) (n=178); overexpression DKK1 indicated the adverse outcome of OS and PFS in PAAD. (E) OS survival curve of bladder urothelial carcinoma (BLCA) (n=402); higher expression of DKK1 was related to poor prognosis of OS in BLCA. (F) PFS survival curve of lung squamous cell carcinoma (LUSC); higher expression of DKK1 was related with shortened PFS in LUSC. DKK1, Dickkopf1; GEPIA, Gene Expression Profiling Interactive Analysis; OS, overall survival.