Table 4. The AEs occurred during combination therapy in 14 comparative studies.

Authors	HFSR (%)	Diarrhea (%)	Fatigue (%)	Hematological events (%)	Alopecia (%)	Hypertension (%)	Nausea (%)	Rash/desquamation (%)
Kudo et al.	82	31	NA	NA	41	31	NA	40
Sansono et al.	10	10	22.5	13	0	15.3	17.5	20
Qu et al.	82.2	48.9	55.6	NA	46.6	55.6	26.6	57.7
Bai et al.	63.4	36.6	24.4	NA	45.1	8.5	NA	NA
Muhammad et al.	15.3	7.7	7.7	NA	NA	7.7	0	NA
Huang et al.	NA	NA	NA	NAT	NA	NA	NA	NA
Hu et al.	14.6	6.1	NA	NA	NA	4.9	NA	NA
Takamasa et al.	NA	NA	NA	NA	NA	NA	NA	NA
Yao et al.	58	38	52	NA	NA	36	NA	20
Hoffmann et al.	29.2	37.5	30.8	54.2	4.2	NA	12.5	NA
Lencioni et al.	46.4	52.9	43.1	20.9	28.1	30.1	37.9	21.6
Zhang et al.	NA	NA	NA	10	NA	NA	NA	NA
Wan et al.	NA	NA	NA	NA	NA	NA	NA	NA
Lee et al.	NA	NA	NA	NA	NA	NA	NA	NA

AEs, adverse events; HFSR, hand foot skin reaction; NA, not available.