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. 2020 Apr;8(8):549. doi: 10.21037/atm-20-2912

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2020 Annals of Translational Medicine. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0.

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The ceRNA network. The blue rounds represent down-regulated protein coding mRNAs, while the red rounds represent up-regulated protein coding mRNAs. The yellow triangles represent miRNAs. The green rhombuses represent circRNAs. The gray solid lines represent the circRNA-miRNA regulatory relationships and the light green lines represent miRNA-mRNA regulatory relationships. The size of the node represents its degree in the network, and the bigger is the node, the higher is the degree. ceRNA, competing endogenous RNA.